I suppose as a rule of thumb you don't want your audience to be confused or need things explained. Every piece should tell a story that the viewer should grasp.* Even if a piece is abstract, like a lot of the abstract Cinema4d #everyday art you find on Instagram, it's obvious that it's abstract. It's just a bunch of fractal metal orbs on floating glass tubes, or whatever - the 'story' of the piece is "isn't C4d cool?? Look what I can do in 40 minutes!". And you don't really need that explained to you.
Even some archviz stuff will be an extreme closeup of a wall, and at first you might think "why am I looking at a palm-sized bit of wall, this is boring", but you realize the point of the piece is the texture of the wall finish and the way the afternoon light slides across it, something is being said about the materiality of human shelter or something. And, maybe, how fun DOF effect is.
Feel welcome to post the piece you're thinking of and we can give you feedback.